Chronic intestinal inflammation, definition of advanced disease and more


As reported by PharmacyTimes®, the results of the study published in Free neuropathology reported that chronic intestinal inflammation can trigger processes in the body that lead to the development of PD.

Using results from an experimental mouse model, researchers found that chronic intestinal inflammation triggers alpha synuclein, a protein that appears to have a central role in the pathogenesis of PD, to agglomerate in the walls of the body. colon and in local immune cells called macrophages.

Additionally, the study suggested that chronic inflammation in the gut early in life may exacerbate the agglutination of alpha synuclein throughout the brain, as found in mouse models, which, according to the researchers, could be caused by the movement of inflammatory chemicals from the gut to the brain. via the bloodstream or potentially via the vagus nerve.

Panelists discuss the definition of advanced PD

In a series of peer-to-peer exchanges NeurologyLive®, titled “Recognizing and Managing Advanced Parkinson’s Disease,” panelists discussed the current definition of advanced PD and how this translates into the recognition and management of the disease.

In the absence of an exact definition of advanced PD, it has been noted that the current understanding of the disease is characterized by several factors and symptoms that progress over time, particularly the time spent with symptom control and the time in l ‘OFF state. Although advanced PD can be perceived by the time since diagnosis, the panelists note that it should rather be a function of the burden of fluctuations in motor and non-motor symptoms.

Discussing the implications of each stage of the disease, one panelist stressed that the key is to understand where each patient is in the process of their disease to match the burden of symptoms with an optimized treatment dosage.

How income and education impacted patient telehealth amid the pandemic

In a Q&A with NeurologyLive®, James Beck, PhD, Scientific Director of the Parkinson Foundation and Assistant Associate Professor in the Department of Neurosciences and Physiology, New York University School of Medicine, discussed the notable challenges in using and accessing healthcare that PD patients have faced amid the COVID -19 pandemic.

With the pandemic causing the care of patients with chronic conditions such as PD to switch to virtual appointments, Beck highlighted the technological barriers present for many patients who are typically in their mid-60s and older. In addition to the gap in technological prowess, a survey of telehealth use in 1,342 PD patients found significant disparities based on income and education.

In the survey results, the highest telehealth use was associated with patients with family income over $ 100,000 per year (odds ratio [OR], 1.54; 95% CI, 1.06-1.76) or post-secondary education (OR, 2.05; 95% CI, 1.16-3.62). However, to assess patient use of care, most used telehealth for doctor’s appointments rather than physical, occupational, or speech-language therapy, with mental health services being cited by respondents as being better in person than in a virtual setting after the pandemic.


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